15/06/2020
It's one of the most popular medicinal plants used for the treatment of array of diseases such as cancer (MCF-7 human breast cancer and HCT-116 colon cancer cell lines), diabetes, high blood pressure, ulcer, leprosy, bronchitis, skin diseases, flatulence, colic, influenza, dysentery, dyspepsia and malaria for Africa Asia, & America continents. It possesses several photochemical constituents with unique and interesting biological properties. phytochemistry, pharmacological activities, toxicity profile and therapeutic usage, in order to bridge the gap requiring future research opportunities. Literature study on scientific journals and books from library and electronic sources. Diterpenes, flavonoids, xanthones, noriridoides and other miscellaneous compounds have been isolated from the plant. Extract and pure compounds of the plant have been reported for their anti-microbial, cytotoxicity, anti-protozoan, anti-inflammatory, anti-oxidant, immunostimulant, anti-diabetic, anti-infective, anti-angiogenic, hepato-renal protective, s*x hormone/s*xual function modulation, liver enzymes modulation INSECTICIDAL and toxicity activities. The results of numerous toxicity evaluations of extracts and metabolites isolated from this plant did not show any significant acute toxicity in experimental animals.