04/22/2026
The most investigated effect of creatine on mental function is in older adults. A 2025 systematic review examined data for over 1500 men and women, with average ages ranging from 67-76 years old. Like most papers that have investigated the impact of creatine on mental function in individuals over 55 years of age, this one concluded that there was a mild improvement in cognitive function.
This might make creatine an attractive supplement for those of us who are older - but buyer beware because when you read the fine print it's not quite that convincing. The only study that was of high quality - where the same subjects were tested under both the baseline and the creatine conditions, where the conditions were in random order, and where both subjects and researchers were unaware of which data set was the supplemented one, was the one study that showed no effect. Almost all the studies that did show positive effects were based on dietary recall, which means that subjects were asked to remember what they ate over past days. If you've ever tried to do that - even if you are highly motivated to be accurate and you are knowledgable about nutrition the accuracy of recall is very poor. When combined with the low degree of cognitive improvement that was reported it makes more sense to put your dollars and energy into things we do know help older adults maintain good function - like diet, hydration, sleep and yes.... FITNESS!