Holiday Inn Express & Suites Cape Girardeau I-55

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Holiday Inn Express & Suites Cape Girardeau I-55 Welcome to Our Cape Girardeau Hotel. Vacation and business guests alike choose these accommodations for a comfortable and convenient stay.
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Just off I- 55 at exit 96, the Holiday Inn Express Hotel & Suites Cape Girardeau I-55 offers hotel guests 102 spacious, contemporary suites. Our Cape Girardeau, Missouri hotel is just minutes from Southeast Missouri State University, where guests are encouraged to cheer on the Redhawks in football and basketball. We're also only 10 miles from Trail of Tears State Park, so families can enjoy picnics, hiking, biking and fishing. Be sure to stop by our Old Downtown area where you will not only enjoy a variety of shops and restaurants, but you can enjoy the great view of the Mississippi River. Business travelers appreciate our Cape Girardeau, Missouri hotel's convenient location close to St. Francis Hospital, Southeast Missouri Hospital, Doctors Park, the Show Me Center, Procter & Gamble, Mondi, Shawnee Park and Biokyowa. We provide two spacious meeting rooms, as well, which feature A/V equipment ideal for business functions or special events. With the help of our professional staff, your event can be a success. At our Girardeau hotel, we know it's the extra perks that make your stay unforgettable. We provide an indoor pool and well-equipped fitness center to help you relax and unwind. Be sure to stop by our breakfast bar each morning, too, for biscuits, eggs, fruit and our signature cinnamon rolls. We look forward to your next visit!

10/20/2026

Sweet, savory, stackable, spoonable… wherever you wake up, there’s something tasty to get out of bed for.

A stay that loves your to-do AND your do-not-disturb.
10/15/2026

A stay that loves your to-do AND your do-not-disturb.

10/06/2026

A winning blend: Costa Coffee and Holiday Inn Express.

09/29/2026

Morning motivation comes standard: Free hot breakfast and Costa Coffee at Holiday Inn Express.

*Offerings vary by region.

09/25/2026

Keep rolling, we’ve got you covered. Everything you need to rest, recharge, and fuel up is ready at Holiday Inn Express by IHG.

09/23/2026

We saved you a spot. It’s next to the cinnamon rolls.

*Offerings vary by region.

09/21/2026

*Books stay for breakfast*

*Offerings vary by region.

It's love at first sip. *Offerings vary by region.
09/19/2026

It's love at first sip.

*Offerings vary by region.

09/17/2026

Game day’s sweetest start.

*Offerings vary by region.

09/16/2026

Wherever you travel, we're there. Cheering you on.

Sleep like you mean it. Rooms designed for maximum comfort, featuring plush duvets, pillow options, and sparkling-clean ...
08/31/2026

Sleep like you mean it. Rooms designed for maximum comfort, featuring plush duvets, pillow options, and sparkling-clean spaces, so you can snooze with confidence.

08/30/2026

Our REM cycle runs on pancakes. Dreamy breakfast + Costa Coffee, free at Holiday Inn Express.

*Offerings vary by region.

07/04/2026
Come celebrate July 4th with us. Celebrating 250 years. Enjoy the Riverfest downtown Cape and fireworks on the River.
06/24/2026

Come celebrate July 4th with us. Celebrating 250 years. Enjoy the Riverfest downtown Cape and fireworks on the River.

We reserved this table in our breakfast room to honor our Fallen Heroes. We are so thankful for your service.
05/22/2026

We reserved this table in our breakfast room to honor our Fallen Heroes.
We are so thankful for your service.

Proud 2025 torchbearer winners. Highest award you can win in the Holiday Inn system for customer service.Proud of our te...
05/13/2026

Proud 2025 torchbearer winners. Highest award you can win in the Holiday Inn system for customer service.
Proud of our team and all they do for our guests!

Happy Mother’s Day weekend! We hope your weekend is the best! 🌸🌼🌻🌷
05/09/2026

Happy Mother’s Day weekend! We hope your weekend is the best! 🌸🌼🌻🌷

Address

3253 William Street
Cape Girardeau, MO
63701

Telephone

+15733344491

Website

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