Holiday Inn Express & Suites Hannibal - Medical Center

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Holiday Inn Express & Suites Hannibal - Medical Center Welcome to Holiday Inn Express & Suites Hannibal - Medical Center, your comfortable base for exploring this storied stretch of northeast Missouri.

Our Hannibal hotel places you close to the Mark Twain Boyhood Home & Museum, the adventure-filled Mark Twain Cave, and scenic views along the Mississippi River. Whether you're here for a quick getaway or to experience the charm of historic downtown, this hotel in Hannibal keeps you connected to the area’s most memorable attractions. Unwind with thoughtful amenities designed to keep your stay easy and enjoyable. Take a dip in the heated indoor pool, stay productive in the dedicated meeting space, or enjoy the convenience of a central location near local businesses and medical centers. Guests also appreciate our 24-hour fitness center, free Wi-Fi, complimentary hot breakfast, and free parking, making it simple to settle in and focus on what matters most.

10/20/2026

Sweet, savory, stackable, spoonable… wherever you wake up, there’s something tasty to get out of bed for.

A stay that loves your to-do AND your do-not-disturb.
10/15/2026

A stay that loves your to-do AND your do-not-disturb.

10/06/2026

A winning blend: Costa Coffee and Holiday Inn Express.

09/29/2026

Morning motivation comes standard: Free hot breakfast and Costa Coffee at Holiday Inn Express.

*Offerings vary by region.

09/25/2026

Keep rolling, we’ve got you covered. Everything you need to rest, recharge, and fuel up is ready at Holiday Inn Express by IHG.

09/23/2026

We saved you a spot. It’s next to the cinnamon rolls.

*Offerings vary by region.

09/21/2026

*Books stay for breakfast*

*Offerings vary by region.

It's love at first sip. *Offerings vary by region.
09/19/2026

It's love at first sip.

*Offerings vary by region.

09/17/2026

Game day’s sweetest start.

*Offerings vary by region.

09/16/2026

Wherever you travel, we're there. Cheering you on.

Sleep like you mean it. Rooms designed for maximum comfort, featuring plush duvets, pillow options, and sparkling-clean ...
08/31/2026

Sleep like you mean it. Rooms designed for maximum comfort, featuring plush duvets, pillow options, and sparkling-clean spaces, so you can snooze with confidence.

08/30/2026

Our REM cycle runs on pancakes. Dreamy breakfast + Costa Coffee, free at Holiday Inn Express.

*Offerings vary by region.

Address

120 Shinn Lane
Hannibal, MO
63401

Telephone

+15732483000

Website

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