Santa Maria Suites Resort

Santa Maria Suites Resort 🌴 Luxury all-suite hotel in Key West just steps from Duval Street. Enjoy 2-bedroom suites with full kitchens, lush gardens, pools, and top-rated service.
(877)

Ideal for families, couples, & friends traveling together. Experience paradise.🌴 Make your escape to the Santa Maria Suites Hotel, an award-winning resort destination in sunny Key West. Located in the heart of the historic district, our property captures the charm and history of Key West while offering a sophisticated, fashion forward style. Our well-appointed 1- and 2-bedroom suites feature luxurious furnishings, complimentary Wi-Fi and garden or pool views.

THANK YOU to all of our guests & wonderful staff for getting us in the Top 10%! 🌎❤️
06/10/2026

THANK YOU to all of our guests & wonderful staff for getting us in the Top 10%! 🌎❤️

Just steps away from The Southernmost Point landmark! Have you been here?
06/09/2026

Just steps away from The Southernmost Point landmark! Have you been here?

⭐️⭐️⭐️⭐️⭐️ “Fabulous place to stay in Key West!!! 2BR suites!!! Very clean and spacious!!! Loved having a washer and dry...
05/31/2026

⭐️⭐️⭐️⭐️⭐️ “Fabulous place to stay in Key West!!! 2BR suites!!! Very clean and spacious!!! Loved having a washer and dryer!!!!! Great place to stay in Key West!!!!“ Susan P.

Get ready for the vacation of your dreams ✨🧳
05/24/2026

Get ready for the vacation of your dreams ✨🧳

05/17/2026

Catch up on some much needed R&R in our beautiful two bedroom, condo inspired suites 💤

⭐️⭐️⭐️⭐️⭐️ “Santa Maria Suites genuinely exceeded all our expectations. The rooms are well appointed, appear newly renov...
05/12/2026

⭐️⭐️⭐️⭐️⭐️ “Santa Maria Suites genuinely exceeded all our expectations. The rooms are well appointed, appear newly renovated, and are spotlessly clean. The staff is SO friendly and accommodating. The location is convenient. Fantastic place to stay with a group.” — Kelly H.

Beauty every where you look ✨
05/06/2026

Beauty every where you look ✨

04/28/2026

Parents… we see you! 👀

Book your stay at Santa Maria Suites for a vacation that’s enjoyable for the whole group!

Your next destination is calling!
04/22/2026

Your next destination is calling!

04/14/2026

⭐️⭐️⭐️⭐️⭐️ “What a find! Fabulous location , rooms are spacious and updated with full kitchens, living area and great balcony. Staff are lovely and pool area is a great bonus. Could easily stay long stays . Highly recommend!” — Cindy D.

Address

1401 Simonton Street
Key West, FL
33040

Opening Hours

Monday 12am - 11:59pm
Tuesday 12am - 11:59pm
Wednesday 12am - 11:59pm
Thursday 12am - 11:59pm
Friday 12am - 11:59pm
Saturday 12am - 11:59pm
Sunday 12am - 11:59pm

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