Holiday Inn Express & Suites St. Louis West-O'Fallon

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Holiday Inn Express & Suites St. Louis West-O'Fallon Welcome to the Holiday Inn Express & Suites - O'Fallon Missouri! > The Holiday Inn Express Hotel & Suites in O'Fallon, MO is located just west of St. Louis.

Our hotel is convenient to Interstate 64 and is near several local attractions and businesses making it the perfect hotel for travelers looking for lodging in O'Fallon. Our O’Fallon hotel is conveniently located near major businesses including Citi, General Motors, Mastercard, APC, Nortek, the Missouri Research Park, and Progress West Hospital, making us an ideal choice for business travelers. When it’s time to relax, you’ll find plenty of fun nearby. We’re just minutes from historic St. Charles, Six Flags St. Louis, and the O’Fallon Sports Complex. And with downtown St. Louis only a short drive away, you can easily explore iconic attractions like the Gateway Arch, Anheuser-Busch Brewery, Laclede’s Landing, and cheer on the Cardinals or the Blues at their home stadiums. Whether you’re here for meetings or memories, our location puts the best of St. Louis within easy reach. Bring the whole family—even the four-legged ones! Our pet-friendly O’Fallon hotel features a heated indoor pool, modern fitness center, and our free Express Start™ breakfast bar with favorites like fresh coffee and signature cinnamon rolls. Explore our latest deals and book your stay today.

10/20/2026

Sweet, savory, stackable, spoonable… wherever you wake up, there’s something tasty to get out of bed for.

A stay that loves your to-do AND your do-not-disturb.
10/15/2026

A stay that loves your to-do AND your do-not-disturb.

10/06/2026

A winning blend: Costa Coffee and Holiday Inn Express.

09/29/2026

Morning motivation comes standard: Free hot breakfast and Costa Coffee at Holiday Inn Express.

*Offerings vary by region.

09/25/2026

Keep rolling, we’ve got you covered. Everything you need to rest, recharge, and fuel up is ready at Holiday Inn Express by IHG.

09/23/2026

We saved you a spot. It’s next to the cinnamon rolls.

*Offerings vary by region.

09/21/2026

*Books stay for breakfast*

*Offerings vary by region.

It's love at first sip. *Offerings vary by region.
09/19/2026

It's love at first sip.

*Offerings vary by region.

09/17/2026

Game day’s sweetest start.

*Offerings vary by region.

09/16/2026

Wherever you travel, we're there. Cheering you on.

Sleep like you mean it. Rooms designed for maximum comfort, featuring plush duvets, pillow options, and sparkling-clean ...
08/31/2026

Sleep like you mean it. Rooms designed for maximum comfort, featuring plush duvets, pillow options, and sparkling-clean spaces, so you can snooze with confidence.

08/30/2026

Our REM cycle runs on pancakes. Dreamy breakfast + Costa Coffee, free at Holiday Inn Express.

*Offerings vary by region.

Address

1175 Technology Drive
O'Fallon, MO
63368

Telephone

+16363004844

Website

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