Mainstay Suites

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Mainstay Suites Live Like Home MAINSTAY SUITES
Being away from home doesn’t mean you have to be out of balance at the MainStay Suites® hotel in Odessa, TX near Comanche Trail.

If you’re looking for a longer stay, this non-smoking Odessa hotel off Highway 385 is a great option for you. We offer easy access to attractions like Odessa College, Stonehenge Replica and Odessa Regional Medical Center in addition to:
McKinney Park
Ector County Coliseum
Globe of the Great Southwest
UTPD
Odessa Municipal Court
Invite your friends, family and colleagues to your next event in our meeting room, get work done in our business center and enjoy amenities like guest laundry services and:
Free hot breakfast
Free WiFi
Free daily newspaper
Free parking
Fitness center
Your spacious suite offers apartment-like living with separate areas for working and relaxing, a fully-equipped kitchen, dishwasher, microwave, refrigerator, desk and 42-inch TV. Live like home at the MainStay Suites. Odessa hotels like ours help you maintain your lifestyle during longer stays while enjoying the perks of hotel living–book now!

10/22/2026

Sweet or savory road trip snacks? Enjoy both—from the hotel waffle bar 🧇 to the unexpected 🍿 movie theater experience, go One More Mile with us across Route 66. Next stop, Odeon Theater in Tucumcari, NM.

📍Comfort Inn & Suites Amarillo East, Amarillo, TX

The recent hurricanes and storms are just a few of the more than 60,000 disasters the American Red Cross responds to eac...
10/22/2026

The recent hurricanes and storms are just a few of the more than 60,000 disasters the American Red Cross responds to each year. Help those affected by disasters big and small, whenever and wherever they occur across the country by donating Choice Privileges® points to the American Red Cross*.

Choice Privileges will extend our match point donations an extra $15,000, bringing our total matching to $30,000. http://ch.social/6182BHX3G6

10/16/2026

Check Into More on Route 66 with Choice Hotels as you visit to the historic Odeon Theater. From live performances and comedy shows to karaoke and video game tournaments, the theater gives audiences an unforgettable reason to make a detour.

📍Comfort Inn & Suites Amarillo East, Amarillo, TX

Cooler days call for a change of scenery. Save 15% on your stay of 2+ nights* when you book by November 16 and stay Octo...
10/16/2026

Cooler days call for a change of scenery. Save 15% on your stay of 2+ nights* when you book by November 16 and stay October 11 through November 30, 2026. Stay must begin Sunday–Thursday. http://ch.social/6180BHJAYp

*Terms apply.

10/14/2026

Johnnie says it best—“Get out on the 2-lane road and see places like this!”

Plan your Route 66 road trip with a pit stop at The Classic Gas and Check Into More with Choice Hotels.

📍Casa de Suenos Old Town Historic Inn, An Ascend Collection Hotel, Albuquerque, NM

10/02/2026

Pumpkin spice and a weekend away, that’s nice. AARP members get 15% off* 2+ night stays. Stay 10/9–10/12. Book now at: http://ch.social/6181BGvxll

*Terms apply.

10/01/2026

Travel tip for anyone with food allergies or dietary restrictions 👇✈️

Having a kitchen where you’re staying can give you a lot more control over what you eat while you travel. At Suburban Studios, part of Choice Hotels Extended Stay, you can cook right in your room and even have groceries delivered so you don’t have to spend part of your trip shopping.

I made this easy meatless stuffed pepper skillet that happens to be vegetarian AND gluten-free. 🌱 Having the flexibility to make meals that work for you is just one more way to stay in your rhythm while you’re away from home.

Broaden your horizons and your options: Check out Suburban Studios, part of Choice Hotels Extended Stay, for your next trip!

Share the gift of travel. Members can now share Choice Privileges® points with other members to get them to their next r...
10/01/2026

Share the gift of travel. Members can now share Choice Privileges® points with other members to get them to their next reward faster! Learn more: http://ch.social/6187BGt4Mh

Get ready to set your OOO! ☀️🌊🏖️Save 25% on 3+ nights* in the Caribbean when you book 8/10–11/13 and stay 9/1–11/30/26. ...
09/24/2026

Get ready to set your OOO! ☀️🌊🏖️Save 25% on 3+ nights* in the Caribbean when you book 8/10–11/13 and stay 9/1–11/30/26. *Terms apply.

http://ch.social/6187BGdn33

09/23/2026

Check Into More on Route 66 and join us at the Classic Gas Museum, a one-of-a-kind spot that’ll inspire you to plan your own adventure. And when you do, Choice Hotels will help you rest and recharge along the way.

📍Casa de Suenos Old Town Historic Inn, An Ascend Collection Hotel, Albuquerque, NM

09/21/2026

A 74-year-old, award-winning restaurant. An American travel museum. A private movie theater tour. Discover the history of Route 66 and Check Into More on the road.

Get inspired. Plan your next road trip, and stay with Choice Hotels.

09/16/2026

From getting ready together to one more coffee before heading home, we’re here for every kind of celebration.

09/04/2026

Been thinking about using your PTO? Let this be your sign. ✨

Use your Choice Privileges® points and make your next getaway happen.

http://ch.social/20260904

Happy 110th b-day to the National Park Service! 🥳Celebrate by donating Choice Privileges® points to the National Park Fo...
08/21/2026

Happy 110th b-day to the National Park Service! 🥳Celebrate by donating Choice Privileges® points to the National Park Foundation & we’ll match up to $25k. Let’s preserve parks for generations to come. 🏔️🌲 🏜️ Learn more: http://ch.social/6181B1lcmR

Experience your college 🏈 team like never before with VIP experiences from Choice Privileges®. Bid points on exclusive a...
08/17/2026

Experience your college 🏈 team like never before with VIP experiences from Choice Privileges®. Bid points on exclusive access like pre-game sideline access, VIP hospitality and more. http://ch.social/6189B1wy5Z

Terms apply.

Address

1801 S. Highway 385
Odessa, TX
79766

Telephone

+14323321010

Website

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