Main Street Inn B&B

Main Street Inn B&B Historic Bed & Breakfast Built In 1882. Quietly elegant, relaxed, warm and welcoming best describes the Main Street Inn.

Originally built in 1882, as the Meyer Hotel, the Main Street Inn B&B has long been considered one of Missouri’s finest bed and breakfast establishments. Having recently undergone an extensive year-long renovation in 2017, Proprietors & Innkeepers, Susan O’Donnell and Patrick Fahey are thrilled to re-open the Main Street Inn B&B and welcome our guests to what we hope will be a truly wonderful expe

rience. Located in the heart of Sainte Genevieve’s Historic District, and surrounded by beautiful wine country, we are just a short one-hour drive from both St. Louis and Cape Girardeau, five hours from Chicago and just a little over four hours from Nashville. If you are looking for a relaxing and peaceful getaway, the Main Street Inn B&B is the perfect destination.

04/18/2025

Located at the corner of North Main and Washington Streets, the Main Street Inn B&B is a cherished Ste. Genevieve landmark. Originally built in 1882 as the Meyer Hotel, it has earned a reputation as one of the finest bed and breakfast establishments in the state.

Step inside and experience a blend of history, elegance, and warm hospitality. Each thoughtfully curated room offers a cozy retreat, while the surrounding area invites exploration of the town's rich heritage. From the moment you arrive, Main Street Inn Bed & Breakfast welcomes you with open arms and promises an unforgettable stay.

Friday evening. Antique Mall, Sainte Genevieve.
11/03/2024

Friday evening. Antique Mall, Sainte Genevieve.

02/12/2024

February evening, backyard, Main Street Inn

Historic Bed & Breakfast Built In 1882.
Quietly elegant, relaxed, warm and welcoming best describes the Main Street Inn.

Look for us at milepost 148, northbound.
05/18/2023

Look for us at milepost 148, northbound.

05/18/2023
Ala Georgia O’Keefe
05/18/2023

Ala Georgia O’Keefe

Spring garden beauty.
05/18/2023

Spring garden beauty.

05/18/2023

Another beautiful Saturday morning.

Historic Bed & Breakfast Built In 1882.
Quietly elegant, relaxed, warm and welcoming best describes the Main Street Inn.

Main Street Inn at night as seen by Tammie Dickerson.
09/26/2021

Main Street Inn at night as seen by Tammie Dickerson.

MAIN STREET INN B&B PARTIALLY REOPENS!Visit our website - www.https://www.mainstrinn.net/ - or contact us at 573-880-75...
05/23/2020

MAIN STREET INN B&B PARTIALLY REOPENS!
Visit our website - www.https://www.mainstrinn.net/ - or contact us at 573-880-7500, today to book your next stay.
We look forward to your visit.

VisitSteGen Visit Missouri DowntownSte.Gen Ste. Genevieve Chamber of Commerce

03/22/2020

To Our Many Past and Future Guests:

To ensure the continued wellbeing of our guests, the Main Street Inn is announcing our temporary closing.

During this closure, we will do a deep clean of all guest rooms and public spaces so that once we reopen, our guests can visit knowing that, upon their arrival, they have a safe and completely healthy environment to enjoy.

We appreciate everyone who has walked through our doors over the past two years and we are very much looking forward to seeing you all again, in the not too distant future.

Your Innkeepers,
Pat Fahey and Susan O’Donnell

We just published our latest newsletter!!! If you have some time, we'd love for you to take a look:https://us3.campaign-...
03/03/2020

We just published our latest newsletter!!! If you have some time, we'd love for you to take a look:
https://us3.campaign-archive.com/?u=76a4257ad4aa664f78816ded6&id=bfd2dbe692

VisitSteGen Downtown Sainte Genevieve Visit Missouri Ste. Genevieve Chamber of Commerce

Once again Sainte Genevieve has been selected as a great place to visit! The February issue of Reader's Digest article "Add These 20 Small Towns to Your 2020 Travel List" recognizes Sainte Genevieve, Missouri. Read all about it and follow Visit Ste Genevieve on Facebook for more updates!

Address

221 N. Main Street
Sainte Genevieve, MO
63670

Telephone

+15738807500

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Our Story

Originally built in 1882, as the Meyer Hotel, the Main Street Inn B&B has long been considered one of Missouri’s finest bed and breakfast establishments. Having undergone an extensive year-long renovation, the Main Street Inn B&B re-opened during the Summer of 2017. Proprietors & Innkeepers, Susan O’Donnell and Patrick Fahey, are more than thrilled to welcome our guests and treat them to what we hope will be a truly wonderful experience. Located in the heart of Sainte Genevieve’s Historic District, and surrounded by beautiful wine country, we are just a short one-hour drive from both St. Louis and Cape Girardeau, five hours from Chicago and just a little over four hours from Nashville. If you are looking for a relaxing and peaceful getaway, the Main Street Inn B&B is the perfect destination.