Holiday Inn Express & Suites St. Louis South - I-55

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Holiday Inn Express & Suites St. Louis South - I-55 Welcome to the new Holiday Inn Express & Suites St. Louis South I-55! South St. Louis has to offer. The hotel is just 14 miles directly south of Downtown St. Louis.

Louis's newest and most modern Holiday Inn Express Hotel nestled within a growing development at the intersection of Butler Hill Road & I-55 just one mile south of I-270/255 with access to everything St. Louis and located at exit #195 from I-55. Business travelers will benefit from our central location with easy on/off access to I-55 that offers access to the different areas of St. Louis within minutes. The hotel complex includes the Barnes-Jewish Siteman Cancer Center & Mercy Health. We are just minutes from Metlife, Anhueser Busch, Cigna and the National Cemetary Association. Our non smoking Holiday Inn Express & Suites St. Louis I-55 hotel is very convenient to guests visiting Busch Stadium, Gateway Arch, Grant's Farm, Magic House, St. Louis Science Center, St. Louis Zoo, Forest Park, River City Casino and much more! Hotel Guests can enjoy an array of amenities including guest room suites, Indoor Pool, Suite Shop, Two Meeting Rooms, Complimentary Express Start Breakfast, Complimentary High Speed Wired & Wireless Internet, Comfortable Great Room with Outdoor Patio and warm Cookies & Milk served nightly. Guests will enjoy our midwest hospitality in South St. Our goal is to make every guest feel at home so that we exceed all of their expectations!

10/20/2026

Sweet, savory, stackable, spoonable… wherever you wake up, there’s something tasty to get out of bed for.

A stay that loves your to-do AND your do-not-disturb.
10/15/2026

A stay that loves your to-do AND your do-not-disturb.

10/06/2026

A winning blend: Costa Coffee and Holiday Inn Express.

09/29/2026

Morning motivation comes standard: Free hot breakfast and Costa Coffee at Holiday Inn Express.

*Offerings vary by region.

09/25/2026

Keep rolling, we’ve got you covered. Everything you need to rest, recharge, and fuel up is ready at Holiday Inn Express by IHG.

09/23/2026

We saved you a spot. It’s next to the cinnamon rolls.

*Offerings vary by region.

09/21/2026

*Books stay for breakfast*

*Offerings vary by region.

It's love at first sip. *Offerings vary by region.
09/19/2026

It's love at first sip.

*Offerings vary by region.

09/17/2026

Game day’s sweetest start.

*Offerings vary by region.

09/16/2026

Wherever you travel, we're there. Cheering you on.

Sleep like you mean it. Rooms designed for maximum comfort, featuring plush duvets, pillow options, and sparkling-clean ...
08/31/2026

Sleep like you mean it. Rooms designed for maximum comfort, featuring plush duvets, pillow options, and sparkling-clean spaces, so you can snooze with confidence.

08/30/2026

Our REM cycle runs on pancakes. Dreamy breakfast + Costa Coffee, free at Holiday Inn Express.

*Offerings vary by region.

Address

4250 Midamerica Lane
St. Louis, MO
63129

Telephone

+13148940700

Website

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